Stem-Like Ovarian Cancer Cells Can Serve as Tumor Vascular Progenitors
نویسندگان
چکیده
منابع مشابه
Stem-like ovarian cancer cells can serve as tumor vascular progenitors.
Neovascularization is required for solid tumor maintenance, progression, and metastasis. The most described contribution of cancer cells in tumor neovascularization is the secretion of factors, which attract various cell types to establish a microenvironment that promotes blood vessel formation. The cancer stem cell hypothesis suggests that tumors are composed of cells that may share the differ...
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Tumor neo-vascularization is critical for tumor growth, invasion and metastasis, which has been considered to be mediated by a mechanism of angiogenesis. However, histopathological studies have suggested that tumor cells might be the progenitor for tumor vasculature. Recently, we have reported that the precancerous stem cells (pCSCs) representing the early stage of developing cancer stem cells ...
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ژورنال
عنوان ژورنال: Stem Cells
سال: 2009
ISSN: 1066-5099,1549-4918
DOI: 10.1002/stem.191